“Molecular Mechanisms of Antipsychotic-induced Insulin Resistance”
This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.
Drug - olanzapine
Drug - placebo
Molecular Mechanisms of Antipsychotic-induced Insulin Resistance in Healthy Volunteers