Clinical Trial

Effect of Heavy Alcohol Consumption on Liver Function

Study Description

Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling

The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver. The abnormality of this pathway may lead to liver injury in some patients who drink heavily.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Placebo

1 tablet of placebo, taken orally daily with water, approximately 30 minutes prior to breakfast for 4 weeks.

Drug - 10 mg Obeticholic Acid (OCA)

10 mg Obeticholic Acid (OCA) Study medication will be administered orally, once daily, approximately 30 minutes prior to breakfast for 4 weeks.

Additional Information

Official Study Title

Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling

Clinical Trial ID

NCT02654236

ParticipAid ID

1aK98d