Self-Activation and Nicotine Dependence

Eligibility Details: Inclusion Criteria: 1. 18-45 years of age 2. Right handed 3. In good general health 4. Male or Female 5. For ND individuals: Self-reported smoking ≥ 5 combustible cigarettes per day 6. For ND individuals: Afternoon expired CO concentration of ≥ 8 ppm 7. For ND individuals: Is willing and able to abstain from smoking for a few hours Exclusion Criteria: 1. History of chronic/significant medical condition 2. Current or past 6 month use of prescription medications for psychiatric conditions (e.g., depression, anxiety) 3. Current or past 6 month diagnosis of anxiety, bipolar disorder, depression, OCD, schizophrenia, psychosis, or personality disorder. 4. Current substance abuse or dependence or history within the last 6 months (other than nicotine for ND individuals) 5. For ND individuals: Positive drug test for anything other than marijuana 6. For ND individuals: Currently on nicotine replacement therapy 7. For ND individuals: Individuals who role their own cigarettes 8. For ND individuals: Daily cannabis use 9. For ND individuals: Consume more than 21 alcoholic drinks per week 10. For ND individuals: Use harder drugs (e.g., cocaine, methamphetamine) more than 10 times per year 11. For ND individuals: Currently taking medication that directly acts on the dopamine system (e.g., L-DOPA). 12. Inability to understand written and/or spoken English language 13. For MRI subjects: Claustrophobia or other contraindications to MRI scanning 14. For MRI subjects: If female, pregnancy as determined by urine pregnancy test on the day of MRI scanning 15. For MRI subjects: Presence of any metal in the body (e.g., implant, non-removable piercing, metal IUD) 16. For MRI subjects: Head injury resulting in loss of consciousness 17. For MRI subjects: Worked with metal (e.g., welding) or had an injury to the eye involving metal 18. For MRI subjects: Weigh more than 250 pounds