Eligibility Details:
Inclusion Criteria:
- Pregnant female presenting to Navy Medical Center San Diego for delivery
- Able to speak and understand English
- Planning to deliver at NMCSD
Exclusion Criteria:
- Age less than 18 years
- Unable to speak or understand English
- Not planning to deliver at NMCSD
- Planned cesarean hysterectomy
- Current anticoagulant use
- Current subarachnoid hemorrhage
- Any active/current intravascular clotting (i.e. venous thromboembolic events)
- Patients with a hypersensitivity to TXA or any of the ingredients
- Personal history of venous or arterial thrombotic events
- Conditions that predispose patients to thromboembolic events (e.g. thrombophilias,
autoimmune diseases such as lupus, active cancer, congestive heart failure, family
history of thrombosis in a first degree relative at age < 30 years) due to increased
risk of thrombosis
- Patients taking factor IX complex concentrates or anti-inhibitor coagulant
concentrates (e.g. FEIBA NF)
- Eclampsia or seizure disorder because the use of tranexamic acid has been associated
with postoperative seizures
- Patients with a baseline creatinine 1.2 or higher, history of renal insufficiency, or
renal disease because of the risk of toxicity in patients with preexisting disease
- Patients with frank hematuria because ureteral obstruction due to clot formation has
been reported in patients with upper urinary tract bleeding who were treated with
tranexamic acid
- Patients with active or history of retinal diseases as cases of central retinal artery
and central retinal vein obstruction have been reported in patients treated with
intravenous tranexamic acid
- Patients with acquired defective color vision