Prevention of Postpartum Hemorrhage with TXA

Eligibility Details: Inclusion Criteria: - Pregnant female presenting to Navy Medical Center San Diego for delivery - Able to speak and understand English - Planning to deliver at NMCSD Exclusion Criteria: - Age less than 18 years - Unable to speak or understand English - Not planning to deliver at NMCSD - Planned cesarean hysterectomy - Current anticoagulant use - Current subarachnoid hemorrhage - Any active/current intravascular clotting (i.e. venous thromboembolic events) - Patients with a hypersensitivity to TXA or any of the ingredients - Personal history of venous or arterial thrombotic events - Conditions that predispose patients to thromboembolic events (e.g. thrombophilias, autoimmune diseases such as lupus, active cancer, congestive heart failure, family history of thrombosis in a first degree relative at age < 30 years) due to increased risk of thrombosis - Patients taking factor IX complex concentrates or anti-inhibitor coagulant concentrates (e.g. FEIBA NF) - Eclampsia or seizure disorder because the use of tranexamic acid has been associated with postoperative seizures - Patients with a baseline creatinine 1.2 or higher, history of renal insufficiency, or renal disease because of the risk of toxicity in patients with preexisting disease - Patients with frank hematuria because ureteral obstruction due to clot formation has been reported in patients with upper urinary tract bleeding who were treated with tranexamic acid - Patients with active or history of retinal diseases as cases of central retinal artery and central retinal vein obstruction have been reported in patients treated with intravenous tranexamic acid - Patients with acquired defective color vision