“Effect of Statin Use on Aldosterone Secretion”
The purpose of this research protocol is to determine if the same effects are observed in vivo in humans through a randomized controlled study. Data regarding a novel mechanism of the widely used statin class of medications on the mineralocorticoid pathway would likely have significant clinical implications on the future management of hypertension and other cardiovascular disease given the known pleiotropy of aldosterone action.
Placebo prepared by Investigation Drug Services at Brigham and Women's Hospital
Drug - Simvastatin
Simvastatin 40 mg daily
Drug - Pravastatin
Pravastatin 80 mg daily
Effect of Statin Use on Aldosterone Secretion