Clinical Trial

Effect of Statin Use on Aldosterone Secretion

Study Description

Effect of Statin Use on Aldosterone Secretion

The purpose of this research protocol is to determine if the same effects are observed in vivo in humans through a randomized controlled study. Data regarding a novel mechanism of the widely used statin class of medications on the mineralocorticoid pathway would likely have significant clinical implications on the future management of hypertension and other cardiovascular disease given the known pleiotropy of aldosterone action.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Placebo

Placebo prepared by Investigation Drug Services at Brigham and Women's Hospital

Drug - Simvastatin

Simvastatin 40 mg daily

Drug - Pravastatin

Pravastatin 80 mg daily

Additional Information

Official Study Title

Effect of Statin Use on Aldosterone Secretion

Clinical Trial ID

NCT02871687

ParticipAid ID

7ax5Bb