Clinical Trial

Antibiotic Irrigations for Intra-Abdominal Drains

Study Description

Antibiotic Irrigations for Intra-Abdominal Drains

Intra-abdominal abscesses are pus-filled pouches in the abdominal cavity. Current standard of care includes drain placement in the abscess cavity to reach source control as well as administration of systemic antibiotics. It is common practice to flush the drain on a daily basis to ensure patency. This study aims to analyze the clinical impact of a higher local concentration of antibiotics (rather than normal saline) provided through drain irrigation with an antimicrobial agent (Gentamicin and/or Clindamycin) compare to normal saline.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Gentamicin Sulfate Inj 20mg/2ml vial for injection

Irrigate surgical drain with total amount of 5 mg in 10 ml volume twice/day for 7 days or until drain removal if less than 7 days of therapy.

Drug - Clindamycin phosphate 6 mg/1ml for injection

Irrigate surgical drain with total amount of 12 mg in 10 ml volume once daily for 7 days or until drain removal if less than 7 days of therapy.

Placebo

The placebo group will receive drain irrigation twice/day

Additional Information

Official Study Title

Antibiotic Irrigations for Intra-Abdominal Drains

Clinical Trial ID

NCT03476941

ParticipAid ID

7axpPa