Blood Based Biomarkers for Pancreas Adenocarcinoma

Eligibility Details: Inclusion Criteria: Cohort 1: Advanced Pancreatic Cancer Cohort Inclusion Criteria - Histological or cytological confirmed diagnosis of locally advanced or metastatic pancreatic adenocarcinoma by the enrolling institution - Patient planning to receive systemic treatment - For stage IV patients, if adjuvant chemotherapy and/or chemoradiation therapy was received for AJCC Stage I-III pancreatic adenocarcinoma, patients are eligible if the last systemic therapy was given more than 6 months before initiation of currently planned systemic therapy - Hemoglobin > 8 - ECOG performance status 0-2 - A minimum age of 18 years old - Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material). New tumor biopsies are not required for entrance into the protocol. Cohort 2: Operable Pancreatic Cancer Cohort Inclusion Criteria - Histological or cytological confirmed diagnosis of pancreatic adenocarcinoma by the enrolling institution - Patient planned to undergo upfront resection - No pre-operative systemic therapy nor chemoradiation therapy planned - Hemoglobin > 8 - ECOG performance status 0-2 - A minimum age of 18 years old - Willing to provide permission to obtain banked tumor tissue for analysis (previous biopsies or surgical material). New tumor biopsies are not required for entrance into the protocol. Cohort 3: Acute Benign Pancreatic Pathology Control Inclusion Criteria - Confirmed diagnosis of acute pancreatitis or other acute pancreatic pathology by the enrolling institution - Hemoglobin > 8 - ECOG performance status 0-2 - A minimum age of 18 years old Cohort 4: Chronic Benign Pancreatic Pathology Control Inclusion Criteria - Confirmed diagnosis of chronic pancreatitis or other non-cystic chronic pancreatic pathology by the enrolling institution - Hemoglobin > 8 - ECOG performance status 0-2 - A minimum age of 18 years old Cohort 5: IPMN Control Inclusion Criteria - Confirmed diagnosis of IPMN without high risk features by the enrolling institution - A minimum age of 18 years old Cohort 6: Pancreatic Cyst Control Inclusion Criteria - Confirmed diagnosis of benign pancreatic cyst by the enrolling institution - A minimum age of 18 years old Cohort 7: Healthy Control Inclusion Criteria - A minimum age of 18 years old Exclusion Criteria: Cohort 1: Advanced Pancreatic Cancer Cohort Exclusion Criteria - Prior therapy for advanced/metastatic disease - Prior history of another malignancy (i.e. colon, prostrate, breast, etc) - Adjuvant therapy for resected disease within the last 6 months - Active second malignancy - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer Cohort 2: Operable Pancreatic Cancer Cohort Exclusion Criteria - Neoadjuvant chemotherapy or radiation therapy is planned - Active second malignancy - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer Cohort 3: Acute Benign Pancreatic Pathology Control Exclusion Criteria - Active or prior malignancy, except prior non-melanoma skin cancer - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures Cohort 4: Chronic Benign Pancreatic Pathology Control Exclusion Criteria - Active or prior malignancy, except prior non-melanoma skin cancer - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures Cohort 5: IPMN Control Exclusion Criteria - IPMN with high risk features or planned resection - Active or prior malignancy, except prior non-melanoma skin cancer - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures Cohort 6: Pancreatic Cyst Control Exclusion Criteria - Active or prior malignancy, except prior non-melanoma skin cancer - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures Cohort 7: Healthy Control Exclusion Criteria - Active or prior malignancy, except prior non-melanoma skin cancer - Proven to be a carrier of a cancer susceptibility gene or family history concerning for genetic predisposition to cancer - Any medical or psychiatric condition that may interfere with ability to comply with protocol procedures