Confocal Endomicroscopy for Non-Erosive Reflux Disease
Study Description
“Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection”
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings. Secondary Objectives: To evaluate the role of probe based endomicroscopy in the diagnosis of NERD by evaluating dilated intercellular spaces, evaluation of IPCL, and quantification of fluorescein leak. Quality of life at study entry and end of study. Compare two medications under study within each group as a subgroup analysis.
Location
Methods
Pharmaceutical medication involved
Patients and healthy individuals accepted
Drug - Proton Pump Inhibitor (PPI) Therapy
Subject will take a proton pump inhibitor (PPI) of their choice (Omeprazole, Esomeprazole, Pantoprazole, or Lansoprazole) 2 times a day for 8 weeks.
Drug - Sucralfate
Subject will take Sucralfate 4 times a day for 8 weeks.
Additional Information
Official Study Title
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection (CENERDD)
Clinical Trial ID
NCT02788591
ParticipAid ID
7e5wYb
