Clinical Trial

Confocal Endomicroscopy for Non-Erosive Reflux Disease

Study Description

Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection

Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings. Secondary Objectives: To evaluate the role of probe based endomicroscopy in the diagnosis of NERD by evaluating dilated intercellular spaces, evaluation of IPCL, and quantification of fluorescein leak. Quality of life at study entry and end of study. Compare two medications under study within each group as a subgroup analysis.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Proton Pump Inhibitor (PPI) Therapy

Subject will take a proton pump inhibitor (PPI) of their choice (Omeprazole, Esomeprazole, Pantoprazole, or Lansoprazole) 2 times a day for 8 weeks.

Drug - Sucralfate

Subject will take Sucralfate 4 times a day for 8 weeks.

Additional Information

Official Study Title

Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection (CENERDD)

Clinical Trial ID

NCT02788591

ParticipAid ID

7e5wYb