Clinical Trial

Autonomic and Cytokines Profiles in Ulcerative Proctitis

Study Description

Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index

In this study, an electrocardiogram signal will be recorded for 30 min in the fasting state, and blood samples for inflammatory cytokines analysis (7 ml) will be taken at the end of the ECG recording; fecal samples will be taken on the experimental day before the study. In addition, ulcerative colitis disease activity index will be assessed using the Mayo scoring system.

Additional Information

Official Study Title

Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

Clinical Trial ID

NCT03259659

ParticipAid ID

9av4rd