Clinical Trial

Dopamine D3 Receptors in Alcohol Use Disorders

Study Description

Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO Study

There is a need to better understand the mechanisms underlying alcohol use and dependence in order to advance the clinical treatment of alcohol dependence. Here, the investigators will use Positron Emission Tomography to determine if there is an up-regulation of D3 receptors in the brains of subjects with alcohol use disorders. The investigators will also investigate the relationship between D3 binding and major phenotypes associated with alcohol use disorders, namely: alcohol cue induced craving and motivation to self-administer alcohol in the laboratory.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

[11C]-(+)-PHNO PET scan

PET scan

Alcohol Self-Administration

Session for assessing motivation for consuming alcohol.

Craving Task

Cue exposure paradigm

MRI scan

MRI scan scan to analyze the PET data will be administered.

Neuropsychological Assessment

Cognitive questionnaires administered over course of study.

Additional Information

Official Study Title

Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO Study

Clinical Trial ID

NCT03037060

ParticipAid ID

9avr0a