“Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury”
This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury).
Procedure - Sham
Room air will be administered instead of episodic hypoxia or supplemental oxygen..
Procedure - Acute episodic hypoxia
The subjects will undergo 30 minutes of baseline monitoring followed by 15 episodes of one minute of episodic hypoxia with supplemental CO2 to maintain isocapnia. This is followed by a 45 minute recovery period.
Procedure - Supplemental oxygen
Supplemental oxygen therapy for 6 weeks
Drug - Trazodone
100mg before bedtime
Drug - Placebo
One placebo pill before-bedtime
Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury