Clinical Trial

Sleep Apnea in Patients with Cervical Spinal Cord Injury

Study Description

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury).

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Procedure - Sham

Room air will be administered instead of episodic hypoxia or supplemental oxygen..

Procedure - Acute episodic hypoxia

The subjects will undergo 30 minutes of baseline monitoring followed by 15 episodes of one minute of episodic hypoxia with supplemental CO2 to maintain isocapnia. This is followed by a 45 minute recovery period.

Procedure - Supplemental oxygen

Supplemental oxygen therapy for 6 weeks

Drug - Trazodone

100mg before bedtime

Drug - Placebo

One placebo pill before-bedtime

Additional Information

Official Study Title

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

Clinical Trial ID

NCT02922894

ParticipAid ID

DbD7Ka