“Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol”
The study will enroll 30 opioid-dependent participants into an open-label pilot outpatient study of methods to facilitate induction and stabilization onto XR-NTX. There will be three different methods of XR-NTX induction using increasing doses of oral naltrexone and buprenophine.
Drug - Buprenorphine
Buprenorphine will be administered daily
Drug - Naltrexone
On study day 2, participants will receive increasing doses of oral naltrexone prior to administration of XR-NTX
Drug - Vivitrol
Participants will receive one 380 i.m. injection on Study day 5 or 10, and another injection 4 weeks later.
Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol