“Menopausal Sleep Fragmentation and Body Fat Gain”
This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin response as a metabolic biomarker for body fat gain.
Drug - Leuprolide Acetate
one injection of open-label intramuscular dose of leuprolide (3.75-mg depot), a gonadotropin-releasing hormone agonist that rapidly suppresses estradiol and temporarily achieves ovarian suppression.
Fragmented sleep will be experimentally induced.
Menopausal Sleep Fragmentation: Impact on Body Fat Gain Biomarkers in Women