Clinical Trial

Effect of Laser on Reversing Chronic Radiation Injury

Study Description

Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury

Radiotherapy, an essential modality in cancer treatment, frequently induces a fibrotic process in the skin which can lead to increased risk of malignancy, poor wound healing, pain and limitation of movement, and permanent loss of skin appendages with hyper/hypopigmentation, decreased sweating and xerosis, posing significant cosmetic and quality of life issues. Advances in laser therapy has led to the use of fractional laser treatment (FLT) to treat fibrosis associated with in hypertrophic scars and morphea, leading to tissue repair, scar remodeling. The investigators propose a pilot clinical study to test the hypothesis that FLT can normalize the fibrotic process and induce normal scar remodeling in patients affected by chronic radiation injury. Understanding and correcting this underlying fibrotic process can help restore normal skin functions in patients affected with chronic radiation dermatitis (RD) and other debilitating fibrotic diseases in dermatology such as scleroderma, morphea, or nephrogenic systemic fibrosis.


Locations Selected Location


No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Device - Fractional CO2 laser treatment

Patient will be treated with fractional laser treatment over the areas with fibrosis.

No treatment

Patient will also have an area that is not being treated with CO2 laser. This is the area not getting treatment.

Additional Information

Official Study Title

Understanding and Reversing Chronic Radiation Dermatitis - A Pilot Study

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ParticipAid ID