“Hormonal Mechanisms of Sleep Restriction - Axis Study”
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Drug - Ketoconazole Pill
Ketoconazole pill is taken 4 times per Inpatient Stay
Drug - Ganirelix
Ganirelix subcutaneous injection is administered twice per Inpatient Stay
Drug - Dexamethasone
Dexamethasone Pills is taken twice per Inpatient Stay
Drug - Dexamethasone Injection
Dexamethasone IV injection is given twice per Inpatient Stay
Drug - Cosyntropin Injectable Product
cosyntropin injection is given twice per Inpatient Stay
Drug - Recombinant Human Luteinizing Hormone
Leutinizing-Releasing Hormone is given 6 IV infusion pulses per Inpatient Visit
Drug - Hydrocortisone Injection
Hydrocortisone IV push is given twice per Inpatient Visit
Drug - Gonadorelin
Gonadorelin IV injection is given twice per Inpatient Stay
Drug - Corticorelin
Corticorelin IV injection is given twice per Inpatient Stay
Drug - Placebo oral capsule
Placebo for ketoconazole are given 4 times per Inpatient Stay
Drug - Saline Solution
Saline Solution (Placebo) for Dexamethasone IV injection or hydrocortisone IV injection given up to four times per Inpatient Stay
Drug - Saline Solution for Injection
Saline Solution (placebo) for ganirelix subcutaneous injection
Hormonal Mechanisms of Sleep Restriction - Axis Study
NCT03142893
PdRvqd