Clinical Trial

Hormonal Mechanisms of Sleep Restriction - Axis Study

Study Description

Hormonal Mechanisms of Sleep Restriction - Axis Study

The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Ketoconazole Pill

Ketoconazole pill is taken 4 times per Inpatient Stay

Drug - Ganirelix

Ganirelix subcutaneous injection is administered twice per Inpatient Stay

Drug - Dexamethasone

Dexamethasone Pills is taken twice per Inpatient Stay

Drug - Dexamethasone Injection

Dexamethasone IV injection is given twice per Inpatient Stay

Drug - Cosyntropin Injectable Product

cosyntropin injection is given twice per Inpatient Stay

Drug - Recombinant Human Luteinizing Hormone

Leutinizing-Releasing Hormone is given 6 IV infusion pulses per Inpatient Visit

Drug - Hydrocortisone Injection

Hydrocortisone IV push is given twice per Inpatient Visit

Drug - Gonadorelin

Gonadorelin IV injection is given twice per Inpatient Stay

Drug - Corticorelin

Corticorelin IV injection is given twice per Inpatient Stay

Drug - Placebo oral capsule

Placebo for ketoconazole are given 4 times per Inpatient Stay

Drug - Saline Solution

Saline Solution (Placebo) for Dexamethasone IV injection or hydrocortisone IV injection given up to four times per Inpatient Stay

Drug - Saline Solution for Injection

Saline Solution (placebo) for ganirelix subcutaneous injection

Additional Information

Official Study Title

Hormonal Mechanisms of Sleep Restriction - Axis Study

Clinical Trial ID

NCT03142893

ParticipAid ID

PdRvqd