Hormonal Mechanisms of Sleep Restriction - Axis Study
Study Description
“Hormonal Mechanisms of Sleep Restriction - Axis Study”
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Location
Methods
Pharmaceutical medication involved
Patients and healthy individuals accepted
Drug - Ketoconazole Pill
Ketoconazole pill is taken 4 times per Inpatient Stay
Drug - Ganirelix
Ganirelix subcutaneous injection is administered twice per Inpatient Stay
Drug - Dexamethasone
Dexamethasone Pills is taken twice per Inpatient Stay
Drug - Dexamethasone Injection
Dexamethasone IV injection is given twice per Inpatient Stay
Drug - Cosyntropin Injectable Product
cosyntropin injection is given twice per Inpatient Stay
Drug - Recombinant Human Luteinizing Hormone
Leutinizing-Releasing Hormone is given 6 IV infusion pulses per Inpatient Visit
Drug - Hydrocortisone Injection
Hydrocortisone IV push is given twice per Inpatient Visit
Drug - Gonadorelin
Gonadorelin IV injection is given twice per Inpatient Stay
Drug - Corticorelin
Corticorelin IV injection is given twice per Inpatient Stay
Drug - Placebo oral capsule
Placebo for ketoconazole are given 4 times per Inpatient Stay
Drug - Saline Solution
Saline Solution (Placebo) for Dexamethasone IV injection or hydrocortisone IV injection given up to four times per Inpatient Stay
Drug - Saline Solution for Injection
Saline Solution (placebo) for ganirelix subcutaneous injection
Additional Information
Official Study Title
Hormonal Mechanisms of Sleep Restriction - Axis Study
Clinical Trial ID
NCT03142893
ParticipAid ID
PdRvqd
