Impact of Escitalopram on Sperm DNA Fragmentation

Eligibility Details: Inclusion Criteria: - Normal semen analyses, or semen analyses with at least 5 million sperm - Normal TUNEL value (<7%) - Willing to engage in at least weekly sexual activity, with a partner or alone for the duration of the 10-week study Exclusion Criteria: - Azoospermia or severe oligospermia (<5million sperm per semen analysis) - Presently attempting to conceive pregnancy - Sexual dysfunction preventing ability to provide semen analysis throughout study or engage in weekly sexual activity - Current psychiatric disorder including: bipolar, mania, depression, generalized anxiety, social phobia, panic attacks, obsessive compulsive disorder, and schizophrenia. - Family history of bipolar disorder, or suicide (including 2nd degree relatives) - Present use of psychotropic agents (prescription or herbal) or anticonvulsants - Use of sleeping pills - Alcohol consumption greater that 2oz/day - Use of illicit drugs - Inability to read, follow instructions or complete questionnaires in English. - Use of hormonal medications in past 3 months (androgens, androgen blockade, anabolic steroids, estrogens, herbal) - Use of medications to enhance sexual function - History of chemotherapy or pelvic radiation - Use of Monoamine Oxidase inhibitors (MAOi's) or tricyclic antidepressants (TCAs) within 14 days - Liver disease