Clinical Trial

Changing Craving and Brain Reactivity to Alcohol Cues

Study Description

Cortical rTMS as a Tool to Change Brain Reactivity to Alcohol Cues

The goal of this investigation is to determine if, in heavy alcohol users, a single session of transcranial magnetic brain stimulation (TMS) over a brain region involved in craving (medial prefrontal cortex) and a brain region involved in cogntive control (dorsolateral prefrontal cortex) can lower an individual's craving and brain response to alcohol cues. This study involves a screening visit, followed by three visits which involve brain imaging (using functional MRI) and brain stimulation (using TMS). There is also an additional Magnetic resonance spectroscopy (MRS) exploratory Aim in which we will measure the concentration of glutamate in the prefrontal cortex before and after a session of TMS.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Device - medial prefrontal cortex

a form of theta burst stimulation that noninvasively induces a depression in brain reactivity

Device - dorsolateral prefrontal cortex

a form of transcranial magnetic stimulation that noninvasively induces an increase in brain reactivity

Device - sham

sham stimulation

Additional Information

Official Study Title

Charleston ARC Clinical Project 4 Cortical rTMS as a Tool to Change Craving and Brain Reactivity to Alcohol Cues

Clinical Trial ID

NCT02939313

ParticipAid ID

QbYB2d