Clinical Trial

Pathophysiology of Orthostatic Intolerance

Study Description

Pathophysiology of Orthostatic Intolerance

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.


Locations Selected Location


Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Radiation - DAXOR

131-I-Human Serum Albumin Blood Volume Assessment Kit

Procedure - QSweat

Quantitative Sweat Testing

Drug - Intrinsic Heart Rate

Atropine 0.04 mg/kg IV in divided doses Propranolol 0.2 mg/kg IV in divided doses

Additional Information

Official Study Title

Pathophysiology of Orthostatic Intolerance

Clinical Trial ID


ParticipAid ID