Clinical Trial

Neural Correlates of Emotion in Depression

Study Description

The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression

There is good evidence to suggest that the pathological version of sadness that people with Major Depression experience could be caused by the failure of the hormone cortisol to properly inhibit sadness-related brain activity in the subgenual cingulate cortex. This project investigates if the subgenual cingulate cortex has become insensitive to cortisol in patients with depression and tests for variants of the cortisol receptor genes that could predispose individuals to develop cortisol insensitivity.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Hydrocortisone acetate

Drug - Placebo

Additional Information

Clinical Trial ID

NCT02837432

ParticipAid ID

Rb427e