Antimalarial Drugs and Malaria Vaccines

Eligibility Details: - INCLUSION CRITERIA: All of the following criteria must be fulfilled for a subject to participate in this trial: 1. Age greater than or equal to 18 and less than or equal to 50 years. 2. In good general health and without clinically significant medical history 3. Reliable access to the clinical trial center and available in the area for more than 1 year 4. Females of childbearing potential must be willing to undergo periodic pregnancy testing and use reliable contraception per protocol when enrolled into LMIV clinical trials (protocol-specific requirements) EXCLUSION CRITERIA: A subject will be excluded from participating in this trial if any one of the following criteria is fulfilled: 1. Pregnant, breastfeeding, or planned pregnancy in the upcoming year. 2. Hemoglobin, white blood cell (WBC), platelets, alanine transaminase (ALT), and creatinine (Cr) outside of local lab normal range (subjects may be included at the investigator s discretion for not clinically significant values outside of normal range). 3. Abnormal urinalysis as defined by positive urine glucose, protein, and hemoglobin. Subject can be included if investigator determine the abnormality is not clinically significant. 4. Anticipated use during the study period, or use within the following periods prior to enrollment: 1. Investigational malaria vaccine within the last five years 2. Chronic systemic immunosuppressive medications (e.g., cytotoxic medications, oral/parental corticosteroids > 0.5 mg/kg/day prednisone or equivalent). Corticosteroid nasal spray for allergic rhinitis and topical corticosteroids for mild, uncomplicated dermatitis are allowed. 3. Recurrent receipt of blood products or immunoglobulins 5. History of: 1. Sickle cell disease 2. Splenectomy or functional asplenia 3. Systemic anaphylaxis 4. Uncontrolled psoriasis or porphyria 6. Clinically significant medical condition, physical examination findings, other clinically significant abnormal laboratory results, or past medical history that may have clinically significant implications for current health status and participation in the study in the opinion of the Investigator. A clinically significant condition or process includes but is not limited to: 1. A process that would affect the immune response, or requires medication that affects the immune response. 2. Any contraindication to repeated phlebotomy. 7. History of or known active cardiac disease including: 1. prior myocardial infarction (heart attack) 2. angina pectoris 3. congestive heart failure 4. valvular heart disease 5. cardiomyopathy 6. pericarditis 7. stroke or transient ischemic attack 8. exertional chest pain or shortness of breath 9. other heart conditions under the care of a doctor 8. Infection with HIV, hepatitis B, and/or hepatitis C 9. Psychiatric condition that precludes compliance with the protocol including but not limited to: 1. Psychosis within the past 3 years 2. Ongoing risk for suicide, or history of suicide attempt or gesture within the past 3 years 10. Suspected or known current alcohol or drug abuse as defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition at the discretion of the PI 11. Any other finding that, in the judgment of the Investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a subject s ability to give informed consent, or increase the risk of having an adverse outcome from participating in the study