“Effects of Severe Negative Energy Balance on Inflammation”
The effects of prolonged negative energy balance, commonly observed in sustained military training and combat operations, on systemic inflammatory responses has not been determined. To define the putative role of energy balance on inflammation and its downstream effects, we will conduct a controlled laboratory study that simulates extensive physiological stressors to determine if inflammation is exacerbated by underfeeding. This design will test the hypothesis that maintaining energy balance will attenuate systemic inflammation and its potential negative effects on whole-body metabolic homeostasis in response to physiological stressors.
Dietary Supplement - Energy Balance
Energy Balance Sufficient food provided to maintain energy balance.
Dietary Supplement - Negative Energy Balance
Negative Energy Balance Insufficient food provided to maintain energy balance resulting in negative energy balance.
Effects of Severe Negative Energy Balance on Inflammation During a Simulated Military Operation