Clinical Trial

Effects of Severe Negative Energy Balance on Inflammation

Study Description

Effects of Severe Negative Energy Balance on Inflammation

The effects of prolonged negative energy balance, commonly observed in sustained military training and combat operations, on systemic inflammatory responses has not been determined. To define the putative role of energy balance on inflammation and its downstream effects, we will conduct a controlled laboratory study that simulates extensive physiological stressors to determine if inflammation is exacerbated by underfeeding. This design will test the hypothesis that maintaining energy balance will attenuate systemic inflammation and its potential negative effects on whole-body metabolic homeostasis in response to physiological stressors.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Dietary Supplement - Energy Balance

Energy Balance Sufficient food provided to maintain energy balance.

Dietary Supplement - Negative Energy Balance

Negative Energy Balance Insufficient food provided to maintain energy balance resulting in negative energy balance.

Additional Information

Official Study Title

Effects of Severe Negative Energy Balance on Inflammation During a Simulated Military Operation

Clinical Trial ID

NCT03524690

ParticipAid ID

ZdPRAa