Expectation of Unpleasant Events in Anxiety Disorders

Eligibility Details: - INCLUSION CRITERIA: - Inclusion criteria for both patients and healthy controls - All subjects must be able to give written informed consent prior to participation in this study. - PATIENTS ONLY: May have DSM-IV-TR diagnoses of an anxiety disorder (GAD; SAD; Panic disorder; specific phobia) or mood disorder (MDD; BP). - PATIENTS ONLY: May be taking the mood stabilizers, Depakote or Lithium Carbonate. - Speaks English or Spanish fluently (subjects with Major Depressive Disorder, healthy volunteers) EXCLUSION CRITERIA: - Exclusion criteria for healthy subjects - Female subjects who are currently pregnant - Subjects who meet DSM-IV criteria for current alcohol or substance abuse - Subjects with a history of alcohol or substance dependence within 6 months prior to screening - Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID-np). Past history of any psychotic disorder or bipolar disorder. - I-Q<80 - Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome for shocks to be delivered on affected arm; organic brain impairment; seizure disorder) likely to interfere with the study. - Subjects who are on a medication that may interfere with the study. - Employee of NIMH or an immediate family member who is a NIMH employee. - Exclusion criteria for patients - Patients who would be unable to comply with study procedures or assessments; - Female patients who are currently pregnant; - Patients who meet DSM-IV criteria for current alcohol or substance abuse - Subjects with a history of alcohol or substance dependence within 6 months prior to screening; - Patients who are on a medication (other than mood stabilizers lithium carbonate or Depakote) that may interfere with the study - Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome; organic brain impairment; seizure disorder) likely to interfere with the study. - Patients will be excluded if they have a current or past history of, delirium, dementia, amnestic disorder, any of the pervasive developmental disorders; or cognitive impairment. - Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID) with the exception of the mood and anxiety disorders. Past history of any psychotic disorder or bipolar disorder.. - IQ<80 - Not speaking English (except patients with MDD who may be Spanish-speaking); Non-English speaking patients with anxiety disorders will not be recruited because the anxiety-related instruments of interest are not validated in Spanish. Subjects with an anxiety disorder who do not speak English fluently will be excluded because two of our primary anxiety-related instruments of interest (PSWQ and POMS) are not validated in languages other than English. - Employee of NIMH or an immediate family member who is an NIMH employee. - Additional exclusion criteria for the exercise substudy: - History of exercise intolerance - History of heart disease - History of pulmonary disease, other than controlled, non-excercise-induced asthma - History of uncontrolled diabetes - Resting heart rate > 90 BPM - Resting systolic pressure> 140mmHG or diastolic blood pressure>90mmHg - Peripheral condition making completion of the exercise impossible, such as severe osteoarthritis or chronic pain - Clinically significant abnormal EKG as determined by MD or NP - Additional exclusion criteria for the active avoidance task - Color blindness