Eligibility Details:
- INCLUSION CRITERIA:
- Inclusion criteria for both patients and healthy controls
- All subjects must be able to give written informed consent prior to participation
in this study.
- PATIENTS ONLY: May have DSM-IV-TR diagnoses of an anxiety disorder (GAD; SAD;
Panic disorder; specific phobia) or mood disorder (MDD; BP).
- PATIENTS ONLY: May be taking the mood stabilizers, Depakote or Lithium Carbonate.
- Speaks English or Spanish fluently (subjects with Major Depressive Disorder,
healthy volunteers)
EXCLUSION CRITERIA:
- Exclusion criteria for healthy subjects
- Female subjects who are currently pregnant
- Subjects who meet DSM-IV criteria for current alcohol or substance abuse
- Subjects with a history of alcohol or substance dependence within 6 months prior
to screening
- Current Axis I psychiatric disorders as identified with the Structured Clinical
Interview for DSM-IV-TR axis disorders, non-patient edition (SCID-np). Past
history of any psychotic disorder or bipolar disorder.
- I-Q<80
- Medical illnesses (such as diabetes or hypertension) or neurological illnesses
(such as carpal tunnel syndrome for shocks to be delivered on affected arm;
organic brain impairment; seizure disorder) likely to interfere with the study.
- Subjects who are on a medication that may interfere with the study.
- Employee of NIMH or an immediate family member who is a NIMH employee.
- Exclusion criteria for patients
- Patients who would be unable to comply with study procedures or assessments;
- Female patients who are currently pregnant;
- Patients who meet DSM-IV criteria for current alcohol or substance abuse
- Subjects with a history of alcohol or substance dependence within 6 months prior
to screening;
- Patients who are on a medication (other than mood stabilizers lithium carbonate
or Depakote) that may interfere with the study
- Medical illnesses (such as diabetes or hypertension) or neurological illnesses
(such as carpal tunnel syndrome; organic brain impairment; seizure disorder)
likely to interfere with the study.
- Patients will be excluded if they have a current or past history of, delirium,
dementia, amnestic disorder, any of the pervasive developmental disorders; or
cognitive impairment.
- Current Axis I psychiatric disorders as identified with the Structured Clinical
Interview for DSM-IV-TR axis disorders, non-patient edition (SCID) with the
exception of the mood and anxiety disorders. Past history of any psychotic
disorder or bipolar disorder..
- IQ<80
- Not speaking English (except patients with MDD who may be Spanish-speaking);
Non-English speaking patients with anxiety disorders will not be recruited
because the anxiety-related instruments of interest are not validated in Spanish.
Subjects with an anxiety disorder who do not speak English fluently will be
excluded because two of our primary anxiety-related instruments of interest (PSWQ
and POMS) are not validated in languages other than English.
- Employee of NIMH or an immediate family member who is an NIMH employee.
- Additional exclusion criteria for the exercise substudy:
- History of exercise intolerance
- History of heart disease
- History of pulmonary disease, other than controlled, non-excercise-induced asthma
- History of uncontrolled diabetes
- Resting heart rate > 90 BPM
- Resting systolic pressure> 140mmHG or diastolic blood pressure>90mmHg
- Peripheral condition making completion of the exercise impossible, such as severe
osteoarthritis or chronic pain
- Clinically significant abnormal EKG as determined by MD or NP
- Additional exclusion criteria for the active avoidance task
- Color blindness