Clinical Trial

MRI Imaging Effects of Cannabis Smoking

Study Description

Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 10 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Diagnostic Test - Cardiopulmonary exercise testing (CPET)

Participants <35 will perform cardiopulmonary exercise testing as a measure of exercise capacity

Diagnostic Test - Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

Diagnostic Test - Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

Diagnostic Test - Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

Diagnostic Test - Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

Diagnostic Test - Pulmonary Function Tests (PFTs)

Participants will have their lung function evaluated using PFTs

Diagnostic Test - Six Minute Walk Test (6MWT)

Participants >35 years of age will perform the six minute walk test as a measure of exercise capacity

Additional Information

Official Study Title

Longitudinal Study of Xenon-129 MRI Imaging of Effects of Cannabis Smoking on Lung Structure and Function

Clinical Trial ID

NCT03909477

ParticipAid ID

aAD7je