Clinical Trial

Vasodilation in Young Adults

Study Description

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

Previous research has identified adenosine triphosphate (ATP) as an important vasodilator that is released from red blood cells during exercise and exposure to hypoxic environments in adult humans. Further, older adults appear to have lower blood flow during both of these stressors and also have lower amounts of ATP released from their red blood cells. However, the contribution of ATP to vasodilation in response to exercise and hypoxia is currently unknown due to the lack of an effective ATP receptor antagonist. We aim to determine whether Vitamin B6 or its metabolite, Pyridoxal-5-Phosphate (PLP) is an effective ATP receptor antagonist.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Adenosine

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Drug - Vitamin B 6

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Drug - Pyridoxal 5'-Phosphate

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Drug - Adenosine Triphosphate

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Drug - Acetylcholine

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Drug - Sodium Nitroprusside

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Drug - Adenosine Diphosphate

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Drug - Adenosine Monophosphate

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Drug - Uridine Triphosphate

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Additional Information

Official Study Title

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

Clinical Trial ID

NCT03738943

ParticipAid ID

aKrYne