“Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach”
The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer [11C]PBR-28.
Drug - PET with radiotracer [11C]PBR-28
[11C]PBR-28 will be injected into subjects' veins during PET scanning.
Affective challenge is the induction of, for example, mood or affective pain.
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach