Brain Microglial Activation in Neuropsychiatric Syndromes

Eligibility Details: Inclusion Criteria: - Must be between 18-45 years old - Males or females - Must be right handed - Must be able to sit unaccompanied for long periods of time with little body movement - Must be illicit drug free at time of scanning as appropriate (UDS negative), - Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder). - Healthy Control volunteers must be medication free (≥ 14 days) - Illicit drug free at time of scanning (verified by negative urine drug screen) Exclusion Criteria: - Must not be a smoker. - Females must not be pregnant or nursing. - Must not suffer from claustrophobia - Must not meet exclusion criteria for MRI scanning (i.e. non-fixed magnetisable objects) - Must not be PBR-28 low or moderate affinity binder - Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.