Clinical Trial

Brain Microglial Activation in Neuropsychiatric Syndromes

Study Description

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer [11C]PBR-28.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - PET with radiotracer [11C]PBR-28

[11C]PBR-28 will be injected into subjects' veins during PET scanning.

Affective challenge

Affective challenge is the induction of, for example, mood or affective pain.

Additional Information

Official Study Title

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

Clinical Trial ID

NCT03705715

ParticipAid ID

aOY8pd