“A Study on the Impact of Rabeprazole-induced Elevated Stomach pH on APO-Dabigatran Exposure in Healthy Volunteers”
Open-label, crossover study recruiting 46 healthy male volunteers comparing the absorption of APO-dabigatran 150 mg per oral (PO) in the absence or presence of a proton pump inhibitor. Participants will serve as their own control when comparing dabigatran exposure in the absence or presence of the proton pump inhibitor, Rabeprazole 20 mg.
Drug - RABEprazole 20 Mg Oral Delayed Release Tablet
Absorption of APO-Dabigatran measured with and without influence of rabeprazole
Drug - APO-Dabigatran 150mg
Absorption of APO-Dabigatran post single dose
Impact of Rabeprazole-induced Elevated Gastric pH on APO-Dabigatran Exposure in Healthy Volunteers