Clinical Trial

Treatment of Graves' Ophthalmopathy

Study Description

ASCEND GO-2: Study of RVT-1401 for the Treatment of Patients With Active, Moderate to Severe Graves' Ophthalmopathy ( GO )

The purpose of the current study is to assess the efficacy and safety/tolerability of three dose regimens of RVT-1401 in the treatment of active, moderate to severe GO patients. In addition, the study is designed to characterize the effect of RVT-1401 exposure on reduction in anti-TSHR IgG

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Drug - RVT-1401 (Administered via subcutaneous injection)

RVT-1401 is a fully human anti-neonatal Fc receptor (FcRn) monoclonal antibody.

Placebo (Administered via subcutaneous injection)

Placebo

Additional Information

Official Study Title

ASCEND GO-2: A Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled Study of RVT-1401 for the Treatment of Patients With Active, Moderate to Severe Graves' Ophthalmopathy

Clinical Trial ID

NCT03938545

ParticipAid ID

av2kna