Clinical Trial

Effects of E-Cigarette Aerosol on Innate Lung Host Defense

Study Description

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use. The responses and the e-cig components exerting these effects on the airways are largely unknown. This study will identify if specific e-cig flavors modify respiratory immune responses. This study will determine the effects of cinnamaldehyde (CA)-containing e-cigarettes on airway epithelial cell ciliary function (i.e., MCC) in humans. Additionally the study will determine the effects of CA-containing e-cigarettes on airway immune cells obtained through induced sputum (SI) after inhalation of CA-containing e-cig aerosols to determine CA-induced effects on a) immune cell function (e.g., phagocytosis, respiratory burst), b) immune cell surface phenotype, and c) mediator production in humans in vivo.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Cinnamaldehyde e-liquid

Participants will inhale an e-liquid that contains cinnamaldehyde from Vapor Shark DNA 250â„¢ e-cigarette device allowing manual control and vapor setting recordings (voltage, wattage, puff volume, and frequency).

PG/VG e-liquid

Participants will inhale an e-liquid that contains PG/VG from the Vapor Shark DNA 250â„¢ e-cigarette device allowing manual control and vapor setting recordings (voltage, wattage, puff volume, and frequency).

Additional Information

Official Study Title

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

Clinical Trial ID

NCT03700892

ParticipAid ID

axk19e