“Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects”
Currently, topical antihistamines and corticosteroids are mainly used for itching relief. However, the over the counter antihistamines are not effective on all itch conditions. Acetaminophen is a popular and widely used OTC drug for pain relief. Although its mode of action is still unknown, recent studies have shown that acetaminophen indirectly activates cannabinoid CB1 receptors. Recent studies have shown that topical cannabinoid agonists are effective for itch relief, the efficacy of topical acetaminophen will be tested for non-histaminergic itch relief.
Drug - Acetaminophen
Topical acetaminophen gel
Drug - Carbomer 980
Topical vehicle gel
Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects