Clinical Trial

Topical Acetaminophen for Itch Relief

Study Description

Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects

Currently, topical antihistamines and corticosteroids are mainly used for itching relief. However, the over the counter antihistamines are not effective on all itch conditions. Acetaminophen is a popular and widely used OTC drug for pain relief. Although its mode of action is still unknown, recent studies have shown that acetaminophen indirectly activates cannabinoid CB1 receptors. Recent studies have shown that topical cannabinoid agonists are effective for itch relief, the efficacy of topical acetaminophen will be tested for non-histaminergic itch relief.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Acetaminophen

Topical acetaminophen gel

Drug - Carbomer 980

Topical vehicle gel

Additional Information

Official Study Title

Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects

Clinical Trial ID

NCT03997851

ParticipAid ID

axkWBe