Clinical Trial

Perioperative Lidocaine and Ketamine in Abdominal Surgery

Study Description

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Lidocaine and ketamine

Perioperative lidocaine and ketamine infusion (see below for dosages and timings)

Drug - Lidocaine

Perioperative lidocaine infusion (1.5 mg/kg bolus followed by an infusion of 2 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)

Drug - Ketamine

Perioperative ketamine infusion (0.5 mg/kg bolus followed by an infusion of 0.3 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)

Drug - Placebo

Perioperative placebo infusion (normal saline)

Additional Information

Official Study Title

Lidocaine and Ketamine in Abdominal Surgery

Clinical Trial ID

NCT04084548

ParticipAid ID

bW6Jva