Clinical Trial

Inflammation and Brain in Post-Traumatic Stress

Study Description

Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress

The proposal aims to determine if non-invasive vagus nerve stimulation(nVNS) will alter: 1) the peripheral inflammatory biomarker profile, 2) the neural correlates of change in pain stimuli and 3) PTSD symptom severity and 4) life quality and function in Veterans with PTSD. The planned inflammatory biomarker and neuroimaging results can 1) promote knowledge of inflammatory and neurobiological mechanisms that contribute to pain in PTSD, and 2) advance the ability to provide targeted neuromodulation based interventions that support improved life quality and function for Veterans. These goals are consistent with the VA's mission to sponsor research examining variables related to pathogenesis, diagnosis, and(ultimately) treatment of neuropsychiatric disorders.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Device - Cervical Transcutaneous Vagus Nerve Stimulation (Active Comparator)

Both sham and active nVNS treatment produce low-voltage electrical signal that induce reliable sensation on subject skin on upper anterior cervical area (overlying carotid artery).

Device - Cervical Transcutaneous Vagus Nerve Stimulation (Sham Comparator)

Both sham and active nVNS treatment produce low-voltage electrical signal that induce reliable sensation on subject skin on upper anterior cervical area (overlying carotid artery).

Additional Information

Official Study Title

Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress

Clinical Trial ID

NCT03858985

ParticipAid ID

bW6K4a