Restoring Molecular Circadian Rhythm
Study Description
“Restoring Molecular Circadian Rhythm”
The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).
Location
Methods
No pharmaceutical medication involved
Patients and healthy individuals accepted
Observational study without intervention
Observational study without intervention
Additional Information
Official Study Title
Exploratory Pilot Study to Discover Genes That Restore the Molecular Circadian Rhythm
Clinical Trial ID
NCT04086589
ParticipAid ID
bYELnb
