Clinical Trial

Restoring Molecular Circadian Rhythm

Study Description

Restoring Molecular Circadian Rhythm

The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Observational study without intervention

Observational study without intervention

Additional Information

Official Study Title

Exploratory Pilot Study to Discover Genes That Restore the Molecular Circadian Rhythm

Clinical Trial ID

NCT04086589

ParticipAid ID

bYELnb