Clinical Trial

Neural Substrates of Irritability in Women

Study Description

Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period. This endocrine manipulation paradigm, which the investigators have shown provokes irritability in past studies, will be used to examine the neurocircuitry underlying irritability under baseline and hormone challenge conditions among women who are hormone sensitive (HS+; n=15) and non-hormone sensitive (HS-; n=15). The long-term goal of this research is to advance understanding of the neural systems underlying both the triggering of and susceptibility to irritability in women. The objective of the current project is to examine whether HS+ show differences in the behavioral activation system relative to HS- under baseline and hormone challenge conditions using functional magnetic resonance imaging (fMRI) and behavioral tests.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Leuprolide Acetate 3.75 MG/ML

3.75 mg/month leuprolide acetate intramuscular injection

Drug - Estradiol 2 Mg tablet

2 mg estradiol tablet

Drug - Micronized progesterone

200 mg micronized progesterone tablets

Additional Information

Official Study Title

Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

Clinical Trial ID

NCT04051320

ParticipAid ID

bkRnNa