Gut-Level Antiinflammatory Activities of Green Tea

Eligibility Details: Inclusion criteria: Individuals with ≥3 of the following established criteria for metabolic syndrome: - Fasting glucose 100-126 mg/dL - Waist circumference >89/>102 cm for females/males - HDL-C <50/<40 mg/dL for females/males - Triglyceride >150 mg/dL - Blood pressure >130/85 mmHg Healthy adults: - Body weight 19-25 kg/m2 - Fasting glucose <100 mg/dL - HDL-C >50/>40 mg/dL for females/males - Triglyceride <150 mg/dL - Blood pressure <120/80 mmHg Exclusion criteria: - Concurrent tea consumption - Use of dietary supplements, prebiotics, or probiotics - Use of antibiotics or antiinflammatory agents - History of liver disease, cardiovascular disease, hypertension (blood pressure >140/90 mmHg), or cancer - History of gastrointestinal disorders, chronic diarrhea, or surgeries - Hemochromatosis - Parkinson's disease - Use of medications to manage diabetes, hypertension, or hyperlipidemia - Use of antipsychotic medications [Clozapine, lithium, Diazepam] - Use of blood thinning medications [Warfarin] - Use of high blood pressure medications [nadolol] - Use of monoamine oxidase inhibitors [selegiline] - Alcohol consumption >2 drinks/d - Smoking tobacco - Vegetarian - Pregnancy, lactation, or recent changes in birth control use for women