Functionally Validated Structural Endpoints for Early AMD

Eligibility Details: Inclusion Criteria: For those in Normal Macular Health or Early AMD: aged ≥ 60 years; either have normal macular health in both eyes at baseline or have early AMD in one eye For Young Normals: aged 20-30 years old; normal macular health in both eyes. Exclusion Criteria: Exclusion for those in normal macular health are: - ANY EYE CONDITION OR DISEASE IN EITHER EITHER (OTHER THAN EARLY CATARACT) THAT CAN IMPAIR VISION INCLUDING: - diabetic retinopathy - glaucoma - ocular hypertension - history of retinal diseases (e.g., retinal vein occlusion, retinal degenerations) - optic neuritis - corneal disease - previous ocular trauma or surgery - REFRACTIVE ERROR >- 6 DIOPTERS - NEUROLOGICAL CONDITIONS THAT CAN IMPAIR VISION OR JUDGEMENT INCLUDING: - multiple sclerosis - Parkinson disease - stroke - Alzheimer disease - seizure disorders - brain tumor - traumatic brain injury - PSYCHIATRIC DISORDERS THAT COULD IMPAIR THE ABILITY: - to follow simple directions - answer questions about health and functioning - or to provide informed consent - DIABETES - ANY MEDICAL CONDITION THAT CAUSES SIGNIFICANT FRALITY OR IS BELIEVED TO BE TERMINAL. Exclusion criteria for the early AMD group: These are identical to those described above, except that it is acceptable for participants to have early AMD (AREDS 2-4) in one eye and be AREDS grade 1 or any stage of AMD in the fellow eye. Exclusion for Young Normals: - ANY EYE CONDITION OR DISEASE IN EITHER EYE (OTHER THAN EARLY CATARACT) THAT CAN IMPAIR VISION INCLUDING: - diabetic retinopathy - glaucoma - ocular hypertension - history of retinal diseases (e.g., retinal vein occlusion, retinal degenerations) - optic neuritis, corneal disease - previous ocular trauma or surgery - RERACTIVE ERROR >=6 DIOPTORS - NEUROLOGICAL CONDITIONS THAT CAN IMPAIR VISION OR JUDGEMENT INCLUDING: - multiple sclerosis - Parkinson disease - stroke - Alzheimer disease - seizure disorders - brain tumor - traumatic brain injury - PSYCHIATRIC DISORDERS THAT COULD IMPAIR THE ABILITY TO: - follow simple directions - answer questions about health and functioning - or to provide informed consent - DIABETES - ANY MEDICAL CONDITION THAT CAUSES SIGNIFICANT FRAILTY OR IS BELIEVED TO BE TERMINAL.