Clinical Trial

Transfusion Associated Dyspnea Profiling

Study Description

Transfusion Associated Dyspnea Profiling

Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs). CRTRs are among the most important, as the leading cause of transfusion-related harm and death. Though there are distinct classifications for these events, real life cases often don't fall neatly into a given category, with outliers regarded as "transfusion associated dyspnea (TAD)". It is unknown what TAD is -- whether it has a unique root cause, is a milder version of other known CRTRs, or is a blend of events. The purpose of this study is to better understand TAD and CRTRs by profiling them through a detailed medical history and more intensive laboratory assessment. This review of CRTRs may improve the quality/validity of final conclusions reported in the health record and to hemovigilance bodies, and uncover the nature of TAD and/or minimize CRTRs defaulting to the TAD category. Our enhanced understanding will advance diagnostic, treatment, and prevention efforts.


Locations Selected Location


No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Diagnostic Test - TADPOL battery (deep clinicolaboratory profile)

profile dimensions: hemolytic allergic cardiorenal inflammatory leukoagglutinating exploratory bioarchive

Additional Information

Official Study Title

Transfusion-Associated Dyspnea: Prospective Observational and Laboratory Assessment

Clinical Trial ID


ParticipAid ID