“Combined Vaginal Misoprostol and Perivascular Vasopressin”
Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal. Additionally, Misoprostol has been looked at as an additional method to decrease operative blood loss given its ability to increase uterine muscle tone, which therefore constricts the amount of blood flow to the uterus.
Drug - Standard
20 units diluted in 100mL of Normal Saline injected laparoscopic needle
Drug - Standard-vaginal misoprostol
20 units diluted in 100mL of Normal Saline injected laparoscopic needle and misoprostol 400 mcg
A Randomized Control Trial of Combined Vaginal Misoprostol and Perivascular Vasopressin During Robotic Myomectomy