Clinical Trial

Propranolol and Stress-Induced Drinking

Study Description

Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol reduces alcohol self-administered in the laboratory. Importantly, the investigators will evaluate whether propranolol counteracts stress-induced effects on alcohol self-administration. Following titration to steady state medication levels over a 2-week period, each subject will complete two laboratory sessions consisting of a well validated method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a 2-hour alcohol self-administration paradigm known to be sensitive to medication effects.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Propranolol

Propranolol Extended Release (160mg/day).

Drug - Placebo

Placebo pill administered orally.

Additional Information

Official Study Title

Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

Clinical Trial ID

NCT03588754

ParticipAid ID

bqxxpa