Clinical Trial

Testing Oxygen Flow Settings for Breathing

Study Description

The Effects of Flow Settings During High Flow Nasal Cannula for Healthy Volunteers and Adult Hypoxemia Patients

High flow nasal cannula (HFNC) delivers oxygen at a flow which exceeds the patient's inspiratory flow demand in order to improve oxygenation. Numerous randomized control trials and meta-analyses have shown that HFNC improves oxygenation and helps avoid intubation in hypoxemic patients, as well as reduce work of breathing, improve ventilation, and decrease hypercapnia in COPD patients. Flow settings play a critical role when using HFNC, as increased flow can reduce inspiratory effort, improve ventilation, and dynamic lung compliance. However, flow rates used in many studies vary widely. The clinical effects of different HFNC flow setting, specifically to match or over than a patients' own inspiratory flow, is still unknown.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

HFNC flow

HFNC flow will be titrated based on the hospital's policy or protocol for hypoxemic patients and research protocol for healthy volunteers

Additional Information

Official Study Title

The Effects of Flow Settings During High Flow Nasal Cannula for Healthy Volunteers and Adult Hypoxemia Patients

Clinical Trial ID

NCT03738345

ParticipAid ID

dBB8Jd