Clinical Trial

Prevalence of Vertebral Fractures in Type 1 Diabetes

Study Description

Prevalence of Vertebral Fractures in Patients With Type 1 Diabetes

Background : Type 1 diabetes is associated with an increased risk of fractures. The mechanisms accounting for this bone fragility are not yet fully understood. The lower bone mineral density (BMD) observed in individuals with type 1 diabetes cannot solely explain the higher fracture incidence. Bone microarchitecture defects significantly contribute to bone fragility. Few studies assessed spine fractures in type 1 diabetes. This cross-sectional multicenter case-control study aims (1) to evaluate the prevalence of asymptomatic vertebral fractures in individuals with type 1 diabetes in comparison to age- and sex-matched healthy controls; (2) to compare individuals with diabetes with vertebral fractures and those without vertebral fracture using clinical, biochemical and radiological parameters.

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Diagnostic Test - Clinical tests

The investigators perform the following clinical tests: vibration threshold test, monofilament test, and height, weight and waist circumference measurement in every participant.

Diagnostic Test - Clinical tests

The investigators perform the following clinical tests: height, weight and waist circumference measurement in every participant.

Diagnostic Test - Biochemical tests

The investigators perform blood and urine tests in every participant.

Diagnostic Test - DXA scan

The investigators perform a dual energy x-ray absorptiometry (DXA scan or osteodensitometry) in every participant.

Diagnostic Test - AGE Reader

The investigators perform a skin AGE (advanced glycation end products) measurement with the AGE Reader machine in every participant.

Additional Information

Official Study Title

Prevalence of Vertebral Fractures in Patients With Type 1 Diabetes (Diabetes Spine Fractures, DenSiFy)

Clinical Trial ID

NCT04064437

ParticipAid ID

dJ6wPd