Clinical Trial

Low-Dose Weekly vs High-Dose Cisplatin

Study Description

Low-Dose Weekly vs High-Dose Cisplatin

This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Drug - High-Dose Cisplatin

Intravenous administration of High-Dose Cisplatin

Drug - Low-Dose Cisplatin

Intravenous administration of Low-Dose Cisplatin

Radiation - Radiotherapy

Participating centres are to follow their local radiation treatment planning and delivery techniques.

Additional Information

Official Study Title

Randomized Trial Comparing Low-Dose Weekly to High-Dose Cisplatin Concurrent With Radiation for Locally Advanced Head and Neck Cancer.

Clinical Trial ID

NCT03649048

ParticipAid ID

dNkLpe