“Low-Dose Weekly vs High-Dose Cisplatin”
This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.
Drug - High-Dose Cisplatin
Intravenous administration of High-Dose Cisplatin
Drug - Low-Dose Cisplatin
Intravenous administration of Low-Dose Cisplatin
Radiation - Radiotherapy
Participating centres are to follow their local radiation treatment planning and delivery techniques.
Randomized Trial Comparing Low-Dose Weekly to High-Dose Cisplatin Concurrent With Radiation for Locally Advanced Head and Neck Cancer.