“Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]”
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
Drug - Methamphetamine
In each arm, subjects will receive doses of methamphetamine.
Drug - Methylphenidate
In each arm, subjects will receive methylphenidate capsules.
Drug - Placebo oral capsule
In each arm, subjects will receive placebo capsules.
Drug - Duloxetine
Subjects will receive duloxetine capsules in the duloxetine arm.
A Novel Drug Combination as a Pharmacotherapeutic for Methamphetamine-Use Disorder