Sensory Evaluation of the Taste of Pediatric Medicines

Eligibility Details: Inclusion Criteria: - Men and women who are between the ages of 18 and 55 years Exclusion Criteria include the following: - For all female participants, a urine pregnancy test will be done on each testing day. Only those with a negative pregnancy test will be allowed to participate in taste testing. - Smokers will be excluded since it alters flavor perception. - Potential subjects will be excluded if they are on drugs with potential serious adverse effects that are mediated through CYP450 3A4 since ritonavir is a potent inhibitor of CYP450 3A4 and could lead to elevated levels of the prohibited drugs if swallowed. The prohibited drugs include the following: - Alfuzosin (Uroxatral; alpha-1-adrenoreceptor antagonist) - Astemizole (Hismanal; antihistamine) - Bepridil (Vascor; calcium channel blocker) - Cerivastatin (Baycol; statin) - Cisapride (Propulsid; GI motility agent) - Dronedarone (multaq; anti-arrhythmic) - Ergotamine (Cafergot, Ergot derivatives) - Flecainide (Tabocor; anti-arrhythmic) - Lovastatin (Altoprev; HMG-CoA Reductase Inhibitor) - Lurasidone (Latuda; antipsychotic) - Midazolam (Versed; sedative/hypnotic) - Pimozide (Orap; antipsychotic) - Ranolazine (Ranexa; anti-anginal) - Simvastatin (Zocor; statin) - Terfenadine (Seldane; antihistamine) - Tinidazole (Tindamax; anti-parasitic) - Trazodone (Desyrel; antidepressant/sedative) - Triazolam (Halcion; sedative) - Warfarin (Coumadin; blood thinner) - Potential subjects will be excluded if they have had current (within the last 24 hours) use of sildenafil (Viagra), tadalafil (Cialis), and verdenafil (Levitra) are also exclusion criteria. These drugs can be used as needed for erectile dysfunction. They are also used as a daily treatment for pulmonary arterial hypertension. With CYP450 3A4 blockade and current use, hypotension, syncope, and prolonged erection are possible. - Potential subjects will be excluded if they have known allergies or hypersensitivity reactions to lopinavir, ritonavir, clindamycin, prednisone, dexamethasone, ibuprofen, 6-mercaptopurine, propylthiouracil, or any of the excipients in the liquid formulations to be tested.