Clinical Trial

Deep rTMS and Varenicline for Smoking Cessation

Study Description

Deep rTMS and Varenicline for Smoking Cessation

The purpose of this study is to investigate the effect of deep repetitive transcranial magnetic stimulation (rTMS) using the insula H-coil on smoking outcomes in smokers receiving varenicline. It is hypothesized that active deep rTMS will improve abstinence rates, attenuate craving and reduce cigarette consumption and dependence severity.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Device - Deep Repetitive Transcranial Magnetic Stimulation (Active)

Active deep rTMS (10 Hz) using the H-coil to target the bilateral insula

Device - Deep Repetitive Transcranial Magnetic Stimulation (Sham)

Sham deep rTMS using the H-coil. The sham coil is built into the same helmet as the active coil. It mimics the active coil with regards to acoustics and scalp sensations.

Drug - Varenicline

12 week course treatment of varenicline (0.5 mg/1 mg) using the standard dosage schedule for smoking cessation (Day 1-3: 0.5 mg daily; day 4-7: 0.5 mg twice a day; day 8-end of treatment: 1 mg twice a day).

Additional Information

Official Study Title

Deep rTMS and Varenicline for Smoking Cessation: A Pilot Study Exploring the Efficacy of a Combined Treatment Approach

Clinical Trial ID

NCT04083144

ParticipAid ID

dPNyWa