Clinical Trial

Induction of Gut Permeability by an Oral Vaccine

Study Description

Induction of Gut Permeability by an Oral Vaccine

This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system. Intestinal and whole-body responses will be measured in all participants before and after the vaccine.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Biological - Vivotif Typhoid Oral Vaccine

One capsule is swallowed on alternate days, e.g. days 15, 17, 19, and 21, for a total of 4 capsules.

Drug - Aspirin (Positive Control)

Three tablets (325 mg aspirin in each tablet or 975 mg total) are swallowed on days 2 and 3.

Additional Information

Official Study Title

Induction of Gut Permeability by an Oral Vaccine

Clinical Trial ID

NCT04083950

ParticipAid ID

dR6AKd