Clinical Trial

Effects of Psilocybin in Post-Traumatic Headache

Study Description

Effects of Psilocybin in Post-Traumatic Headache

The purpose of this study is to investigate the effects of oral psilocybin in post-traumatic headache. Subjects will be randomized to receive placebo, low dose psilocybin, or high dose psilocybin on two separate test days approximately 14 days apart. Subjects will maintain a headache diary prior to, during, and after the treatments in order to document headache frequency and intensity, as well as associated symptoms. Blood samples will be drawn at various timepoints to measure levels of inflammatory peptides.

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Placebo oral capsule

microcrystalline cellulose capsule

Drug - Low Dose Psilocybin

0.0143 mg/kg psilocybin capsule

Drug - High Dose Psilocybin

0.143 mg/kg psilocybin capsule

Additional Information

Official Study Title

Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study II

Clinical Trial ID

NCT03806985

ParticipAid ID

dR6k0d