Clinical Trial

Surveillance AFter Extremity Tumor surgerY

Study Description

Surveillance AFter Extremity Tumor surgerY

Following treatment for a primary extremity sarcoma, patients remain at risk for the development of local and systemic disease recurrence. Metastasis (distant recurrence) to the lung is the most frequent single location of disease recurrence in sarcoma patients, occurring in almost half of all patients. Therefore, careful post-operative surveillance is an integral element of patient care. However, the detection of metastases does not necessarily affect long-term survival and may negatively impact quality of life. Surveillance strategies have not been well researched and have been identified as the top research priority in the extremity sarcoma field. Using a 2X2 factorial design to maximize efficiency and reduce overall trial costs, the SAFETY trial will randomize 830 extremity soft-tissue sarcoma (STS) patients to determine the effect of surveillance strategy on overall patient survival after surgery for a STS of the extremity by comparing the effectiveness of both surveillance frequency (every 3 vs. every 6 months) and imaging modality (CT scans vs. chest radiographs).

Location

Locations Selected Location

Methods

No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Frequency: Every 3 Months

every 3 months

Frequency: Every 6 Months

every 6 months

Imaging Modality: Chest Radiograph (CXR)

Chest radiograph (CXR)

Imaging Modality: Chest CT

Chest computed tomography (CT)

Additional Information

Official Study Title

Surveillance AFter Extremity Tumor surgerY (SAFETY) International Randomized Controlled Trial

Clinical Trial ID

NCT03944798

ParticipAid ID

dyPx6b