Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

Eligibility Details: Inclusion: 1. female who is currently pregnant (8-22 weeks gestational age (GA) at time of screen) 2. 21-45 years old 3. single gestation 4. fluently speak English 5. be available and physically able to attend scheduled group meetings 6. have a prior history of at least 1 major depressive episode (as determined through psychiatric interviewing). Exclusion (at enrollment): 1. Magnetic Resonance Imaging (MRI) contraindication (e.g., metal in their body) 2. major neurological or medical illness (e.g., diabetes, multiple sclerosis) 3. history of head trauma (loss of conscious > 2 minutes) 4. Intelligence Quotient (IQ) < 80 5. uncorrectable vision or hearing impairments (including color blindness) 6. use of psychotropic medications, corticosteroids, insulin, or any other medications that might impact the central nervous system 7. current illicit drug use or diagnosis of a current substance use disorder 8. current diagnosis of an eating disorder 9. current depressive or manic episode 10. diagnosis of a neurodevelopmental disorder (Autism, Intellectual Disability) 11. any history of psychosis 12. current active suicidality and/or homicidality, or interpersonal violence 13. prior history of engaging in mindfulness-based psychotherapeutic interventions (e.g., Mindfulness Based Cognitive Therapy (MBCT), Mindfulness Based Stress Reduction (MBSR), Dialectical Behavior Therapy (DBT)) 14. known congenital, genetic, or neurologic disorder of the fetus (e.g., Down syndrome, fragile X) 15. pregnancy-specific medical conditions or complications that significantly increase risk (e.g., placental separation, placenta previa) 16. History of meningitis or seizures (except infantile or febrile)