Clinical Trial

Systematic Evaluation of Protamine Doze in Cardiac Surgery

Study Description

Systematic Evaluation of Protamine Doze in Cardiac Surgery

The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary bypass (CPB).

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Drug - Protamine Sulfate

Protamine Sulfate will be administered via an infusion pump to administer a 50 mg test doze, then 100 mg after 5 min waiting period. Following blood samples, additional alliquots of 50 mg will be measured to a maximum of 300 mg.

Additional Information

Official Study Title

Sysytematic Evaluation of Heparin and Protamine in Cardiac Surgery

Clinical Trial ID

NCT03787641

ParticipAid ID

e31Orb