“Systematic Evaluation of Protamine Doze in Cardiac Surgery”
The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary bypass (CPB).
Drug - Protamine Sulfate
Protamine Sulfate will be administered via an infusion pump to administer a 50 mg test doze, then 100 mg after 5 min waiting period. Following blood samples, additional alliquots of 50 mg will be measured to a maximum of 300 mg.
Sysytematic Evaluation of Heparin and Protamine in Cardiac Surgery