Clinical Trial

Testing Drug and Vitamin Interaction

Study Description

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

Subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim to determine whether taking a drug and a vitamin together affects the body's ability to absorb, distribute, and eliminate thiamine (Vitamin B1).

Location

Locations Selected Location

Methods

Pharmaceutical medication involved Pharmaceutical medication involved
Patients and healthy individuals accepted Patients and healthy individuals accepted

Drug - Trimethoprim

300mg of trimethoprim will be given in combination with 5mg thiamine and compared to 5mg thiamine only

Drug - Metformin

1000mg of metformin will be given in combination with 5mg thiamine and compared to 5mg thiamine only

Dietary Supplement - Vitamin B1

5mg of thiamine will be given alone and in combination

Additional Information

Official Study Title

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

Clinical Trial ID

NCT03746106

ParticipAid ID

e5yARe